Journalist Eddie Brock is trying to take down Carlton Drake, the notorious and brilliant founder of the Life Foundation. While investigating one of Drake's experiments, Eddie's body merges with the alien Venom -- leaving him with superhuman strength and power. Twisted, dark and fuelled by rage, Venom tries to control the new and dangerous abilities that Eddie finds so intoxicating.

Eddie Brock is still struggling to coexist with the shape-shifting extraterrestrial Venom. When deranged serial killer Cletus Kasady also becomes host to an alien symbiote, Brock and Venom must put aside their differences to stop his reign of terror.

As Eddie and Venom are tirelessly pursued by forces from both of their worlds, they find themselves out of options and left with a shattering last resort.