Reporter Angela (Jennifer Carpenter) and her cameraman Scott (Steve Harris) are doing a story on night-shift firefighters for a reality-TV program. A late-night distress call takes them to a Los Angeles apartment building, where the police are investigating a report of horrific screams. The TV team and emergency workers find an old woman, who suddenly attacks with teeth bared. What's more, Angela and company find that the building has been sealed by CDC workers. Then the attacks really begin.

Passengers on a plane from Los Angeles are in danger when a man takes ill. The viral outbreak turns innocent people into bloodthirsty monsters and the plane lands at an isolated terminal.